Delayed-Onset Dystonia Due to Perinatal Asphyxia : A Prospective Study
Identifieur interne : 003100 ( Main/Exploration ); précédent : 003099; suivant : 003101Delayed-Onset Dystonia Due to Perinatal Asphyxia : A Prospective Study
Auteurs : Natasa Cerovac [Serbie] ; Igor Petrovic [Serbie] ; Christine Klein [Allemagne] ; Vladimir S. Kostic [Serbie]Source :
- Movement disorders [ 0885-3185 ] ; 2007.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Prospective.
English descriptors
- KwdEn :
Abstract
The objective of this work was to establish the existence and incidence of possible delayed-onset dystonia in a cohort of infants with diagnosed perinatal asphyxial hypoxic-ischemic encephalopathy (HIE). This prospective study comprised 103 survivors of perinatal asphyxial HIE, who were regularly followed and neurologically examined in the course of 7 to 13 years after birth (median 10 years). Neurological outcome at the end of the follow-up period was normal in 87 (84.5%) patients, while in 7 (6.8%) only mild neurological signs were detected (behavioral disturbances in 3, clumsiness in 2, and hypotonia in 1 patient). Severe cerebral palsy was diagnosed in nine patients (8.7%). Only one patient was diagnosed with possible delayed-onset segmental dystonia. At the age of 4 years he developed cervical dystonia with spread to one arm in the course of 1.5 years (segmental dystonia) and then stabilized. Other known causes of dystonia, including a DYTI mutation, were excluded. Our preliminary data suggest that over the course of at least 7 years after birth, approximately 1% of infants who survived perinatal asphyxial HIE would develop delayed-onset dystonia.
Affiliations:
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Clinical Center of Serbia</s1><s2>Belgrade</s2><s3>SRB</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Serbie</country><wicri:noRegion>Institute of Neurology. Clinical Center of Serbia</wicri:noRegion></affiliation></author><author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, University of Liibeck</s1><s2>Lübeck</s2><s3>DEU</s3><sZ>3 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>University of Liibeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Human Genetics, University of Liibeck</s1><s2>Lübeck</s2><s3>DEU</s3><sZ>3 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>University of Liibeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Kostic, Vladimir S" sort="Kostic, Vladimir S" uniqKey="Kostic V" first="Vladimir S." last="Kostic">Vladimir S. Kostic</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Neurology. Clinical Center of Serbia</s1><s2>Belgrade</s2><s3>SRB</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Serbie</country><wicri:noRegion>Institute of Neurology. Clinical Center of Serbia</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Asphyxia</term><term>Dystonia</term><term>Encephalopathy</term><term>Hypoxia</term><term>Ischemia</term><term>Nervous system diseases</term><term>Perinatal</term><term>Prospective</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Dystonie</term><term>Asphyxie</term><term>Hypoxie</term><term>Ischémie</term><term>Encéphalopathie</term><term>Pathologie du système nerveux</term><term>Périnatal</term><term>Prospective</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Prospective</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The objective of this work was to establish the existence and incidence of possible delayed-onset dystonia in a cohort of infants with diagnosed perinatal asphyxial hypoxic-ischemic encephalopathy (HIE). This prospective study comprised 103 survivors of perinatal asphyxial HIE, who were regularly followed and neurologically examined in the course of 7 to 13 years after birth (median 10 years). Neurological outcome at the end of the follow-up period was normal in 87 (84.5%) patients, while in 7 (6.8%) only mild neurological signs were detected (behavioral disturbances in 3, clumsiness in 2, and hypotonia in 1 patient). Severe cerebral palsy was diagnosed in nine patients (8.7%). Only one patient was diagnosed with possible delayed-onset segmental dystonia. At the age of 4 years he developed cervical dystonia with spread to one arm in the course of 1.5 years (segmental dystonia) and then stabilized. Other known causes of dystonia, including a DYTI mutation, were excluded. Our preliminary data suggest that over the course of at least 7 years after birth, approximately 1% of infants who survived perinatal asphyxial HIE would develop delayed-onset dystonia.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Serbie</li></country></list><tree><country name="Serbie"><noRegion><name sortKey="Cerovac, Natasa" sort="Cerovac, Natasa" uniqKey="Cerovac N" first="Natasa" last="Cerovac">Natasa Cerovac</name></noRegion><name sortKey="Kostic, Vladimir S" sort="Kostic, Vladimir S" uniqKey="Kostic V" first="Vladimir S." last="Kostic">Vladimir S. Kostic</name><name sortKey="Petrovic, Igor" sort="Petrovic, Igor" uniqKey="Petrovic I" first="Igor" last="Petrovic">Igor Petrovic</name></country><country name="Allemagne"><noRegion><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name></noRegion><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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